The problem with the Box and One is the designed best defender. If the engine pick a big men definitely it's not gonna work.
By the way, considering how weird would be finding a team playing R&G with only one valuable scorer from the outside, I would consider more seriously using the Box to defend the outside and the "one" to defend the best interior player. The only problem with the Box is having enough good players, the have to be versatile.
In general, I do believe 3-2 zone should be the easiest option (assuming having 3 players with OD is not so uncommon). 1-3-1 is too extreme, m2m is valuable but it depends how tough are the matchup created for your guys